Is Dodine a Protein Stabilizer or Destabilizer? It'S Complicated!

Effects of ligand binding on the stability of aldo–keto reductases: Implications for stabilizer or destabilizer chaperones

Ligands such as enzyme inhibitors stabilize the native conformation of a protein upon binding to the native state, but some compounds destabilize the native conformation upon binding to the non-native state. The former ligands are termed "stabilizer chaperones" and the latter ones "destabilizer chaperones." Because the stabilization effects are essential for the medical chaperone (MC) hypothesi...

Quantifying why urea is a protein denaturant, whereas glycine betaine is a protein stabilizer.

To explain the large, opposite effects of urea and glycine betaine (GB) on stability of folded proteins and protein complexes, we quantify and interpret preferential interactions of urea with 45 model compounds displaying protein functional groups and compare with a previous analysis of GB. This information is needed to use urea as a probe of coupled folding in protein processes and to tune mol...

The Human EMAP-Like Protein-70 is a Microtubule Destabilizer that Localizes to the Mitotic Apparatus

Genetic Analysis of Dodine

HERE has been a small amount of published information on the genetics of the heterothallic ascomycete causing root and fruit rot of cucurbits. In these publications the fungus has been referred to as Hypomyces solani f. cucurbitae. However, according to DINGLEY (1961), this organism belong to the species Nectria haenzatococca and should be called N . haematococca var. cucurbitae. Genetic knowle...

Is a Single dose of Prophylactic Antibiotics Sufficient in Patients with Acute Non-Complicated Appendicitis?

Background: Acute appendicitis is one of the most common acute surgery events. Its main treatment is surgery. However medical management before and after the surgery has an important impact on the treatment. Objective: The aim of study was evaluating the outcomes of single dose and quadruple doses of prophylactic antibiotic therapy in patients with acute ...